Human DPYD activation kit by CRISPRa

CAT#: GA101259

DPYD CRISPRa kit - CRISPR gene activation of human dihydropyrimidine dehydrogenase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DPYD
• Locus ID: 1806
• Kit Components:

  GA101259G1, DPYD gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101259G2, DPYD gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101259G3, DPYD gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000110, NM_001160301
• Synonyms: DHP; DHPDHASE; DPD
• Summary: 'The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]'