Human Dopamine Receptor D3 (DRD3) activation kit by CRISPRa

CAT#: GA101267

DRD3 CRISPRa kit - CRISPR gene activation of human dopamine receptor D3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DRD3
• Locus ID: 1814
• Kit Components:

  GA101267G1, Dopamine Receptor D3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101267G2, Dopamine Receptor D3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101267G3, Dopamine Receptor D3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000796, NM_001282563, NM_001290809, NM_033658, NM_033659, NM_033660, NM_033663
• Synonyms: D3DR; ETM1; FET1
• Summary: 'This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]'