Human DUSP1 activation kit by CRISPRa

CAT#: GA101293

DUSP1 CRISPRa kit - CRISPR gene activation of human dual specificity phosphatase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DUSP1
• Locus ID: 1843
• Kit Components:

  GA101293G1, DUSP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101293G2, DUSP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101293G3, DUSP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004417
• Synonyms: CL100; HVH1; MKP-1; MKP1; PTPN10
• Summary: 'The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]'