Human DYRK1A activation kit by CRISPRa

CAT#: GA101306

DYRK1A CRISPRa kit - CRISPR gene activation of human dual specificity tyrosine phosphorylation regulated kinase 1A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DYRK1A
• Locus ID: 1859
• Kit Components:

  GA101306G1, DYRK1A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101306G2, DYRK1A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101306G3, DYRK1A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001396, NM_101395, NM_130436, NM_130437, NM_130438, NM_001347721, NM_001347722, NM_001347723
• Synonyms: DYRK; DYRK1; HP86; MNB; MNBH; MRD7
• Summary: 'This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]'