Human ECM1 activation kit by CRISPRa

CAT#: GA101321

ECM1 CRISPRa kit - CRISPR gene activation of human extracellular matrix protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ECM1
• Locus ID: 1893
• Kit Components:

  GA101321G1, ECM1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101321G2, ECM1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101321G3, ECM1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001202858, NM_004425, NM_022664
• Synonyms: URBWD
• Summary: 'This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011]'