Human EDG1 (S1PR1) activation kit by CRISPRa

CAT#: GA101324

S1PR1 CRISPRa kit - CRISPR gene activation of human sphingosine-1-phosphate receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: S1PR1
• Locus ID: 1901
• Kit Components:

  GA101324G1, EDG1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101324G2, EDG1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101324G3, EDG1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001400, NM_001320730
• Synonyms: CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; S1P1
• Summary: 'The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]'