Human Endothelin B Receptor (EDNRB) activation kit by CRISPRa

CAT#: GA101331

EDNRB CRISPRa kit - CRISPR gene activation of human endothelin receptor type B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EDNRB
• Locus ID: 1910
• Kit Components:

  GA101331G1, Endothelin B Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101331G2, Endothelin B Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101331G3, Endothelin B Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000115, NM_001122659, NM_001201397, NM_003991
• Synonyms: ABCDS; ET-B; ET-BR; ETB; ETBR; ETRB; HSCR; HSCR2; WS4A
• Summary: 'The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]'