Human CELSR2 activation kit by CRISPRa

CAT#: GA101351

CELSR2 CRISPRa kit - CRISPR gene activation of human cadherin EGF LAG seven-pass G-type receptor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CELSR2
• Locus ID: 1952
• Kit Components:

  GA101351G1, CELSR2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101351G2, CELSR2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101351G3, CELSR2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001408
• Synonyms: ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3
• Summary: 'The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]'