Human EIF4EBP1 activation kit by CRISPRa

CAT#: GA101370

EIF4EBP1 CRISPRa kit - CRISPR gene activation of human eukaryotic translation initiation factor 4E binding protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EIF4EBP1
• Locus ID: 1978
• Kit Components:

  GA101370G1, EIF4EBP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101370G2, EIF4EBP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101370G3, EIF4EBP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004095
• Synonyms: 4E-BP1; 4EBP1; BP-1; PHAS-I
• Summary: 'This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]'