Human ELAVL2 activation kit by CRISPRa

CAT#: GA101379

ELAVL2 CRISPRa kit - CRISPR gene activation of human ELAV like RNA binding protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ELAVL2
• Locus ID: 1993
• Kit Components:

  GA101379G1, ELAVL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101379G2, ELAVL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101379G3, ELAVL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001171195, NM_001171197, NM_004432, NM_001351455, NM_001351456, NM_001351457, NM_001351458, NM_001351459, NM_001351460, NM_001351461, NM_001351462, NM_001351463, NM_001351464, NM_001351465, NM_001351466, NM_001351467, NM_001351468, NM_001351469, NM_001351470, NM_001351471, NM_001351472, NM_001351473, NM_001351474, NM_001351475, NM_001351476, NM_001351477, NM_001351478
• Synonyms: HEL-N1; HELN1; HUB
• Summary: 'In humans, the ELAV like RNA binding protein gene family has four members (ELAVL1-4). ELAVL RNA binding proteins recognize AU-rich elements in the 3' UTRs of gene transcripts and thereby regulate gene expression post-transcriptionally. The protein encoded by this gene binds to several 3' UTRs, including its own and also that of FOS, ID, and POU5F1. This gene encodes ELAVL2 and, like ELAVL3 and ELAVL4, is expressed specifically in neurons and primarily localizes to the cytoplasm. This protein also forms a cytosolic complex with the normally nuclear-localized ELAVL1 protein. Alternative splicing of this gene results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Jul 2020]'