Human ELAVL1 activation kit by CRISPRa

CAT#: GA101380

ELAVL1 CRISPRa kit - CRISPR gene activation of human ELAV like RNA binding protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ELAVL1
• Locus ID: 1994
• Kit Components:

  GA101380G1, ELAVL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101380G2, ELAVL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101380G3, ELAVL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001419
• Synonyms: ELAV1; Hua; HUR; MelG
• Summary: 'The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]'