Human HuC (ELAVL3) activation kit by CRISPRa

CAT#: GA101381

ELAVL3 CRISPRa kit - CRISPR gene activation of human ELAV like RNA binding protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ELAVL3
• Locus ID: 1995
• Kit Components:

  GA101381G1, HuC gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101381G2, HuC gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101381G3, HuC gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001420, NM_032281
• Synonyms: HUC; HUCL; PLE21
• Summary: 'A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'