Human EMX2 activation kit by CRISPRa

CAT#: GA101401

EMX2 CRISPRa kit - CRISPR gene activation of human empty spiracles homeobox 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EMX2
• Locus ID: 2018
• Kit Components:

  GA101401G1, EMX2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101401G2, EMX2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101401G3, EMX2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001165924, NM_004098
• Synonyms: empty spiracles homeobox 2; empty spiracles homolog 2; OTTHUMP00000020578
• Summary: 'This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009]'