Human CD105 (ENG) activation kit by CRISPRa

CAT#: GA101405

ENG CRISPRa kit - CRISPR gene activation of human endoglin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ENG
• Locus ID: 2022
• Kit Components:

  GA101405G1, CD105 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101405G2, CD105 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101405G3, CD105 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000118, NM_001114753, NM_001278138
• Synonyms: END; HHT1; ORW1
• Summary: 'This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]'