Human ENT1 (SLC29A1) activation kit by CRISPRa

CAT#: GA101411

SLC29A1 CRISPRa kit - CRISPR gene activation of human solute carrier family 29 member 1 (Augustine blood group)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC29A1
• Locus ID: 2030
• Kit Components:

  GA101411G1, ENT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101411G2, ENT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101411G3, ENT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001078174, NM_001078175, NM_001078176, NM_001078177, NM_001304462, NM_001304463, NM_001304465, NM_001304466, NM_004955
• Synonyms: ENT1
• Summary: 'This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]'