Human HIF 2 alpha (EPAS1) activation kit by CRISPRa

CAT#: GA101413

EPAS1 CRISPRa kit - CRISPR gene activation of human endothelial PAS domain protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EPAS1
• Locus ID: 2034
• Kit Components:

  GA101413G1, HIF 2 alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101413G2, HIF 2 alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101413G3, HIF 2 alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001430
• Synonyms: bHLHe73; ECYT4; HIF2A; HLF; MOP2; PASD2
• Summary: 'This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]'