Human Eph receptor B4 (EPHB4) activation kit by CRISPRa

CAT#: GA101429

EPHB4 CRISPRa kit - CRISPR gene activation of human EPH receptor B4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EPHB4
• Locus ID: 2050
• Kit Components:

  GA101429G1, Eph receptor B4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101429G2, Eph receptor B4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101429G3, Eph receptor B4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004444
• Synonyms: HTK; MYK1; TYRO11
• Summary: 'Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]'