Human Fibrillarin (FBL) activation kit by CRISPRa

CAT#: GA101458

FBL CRISPRa kit - CRISPR gene activation of human fibrillarin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FBL
• Locus ID: 2091
• Kit Components:

  GA101458G1, Fibrillarin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101458G2, Fibrillarin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101458G3, Fibrillarin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001436
• Synonyms: FIB; FLRN; RNU3IP1
• Summary: 'This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]'