Human ETFA activation kit by CRISPRa

CAT#: GA101467

ETFA CRISPRa kit - CRISPR gene activation of human electron transfer flavoprotein subunit alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ETFA
• Locus ID: 2108
• Kit Components:

  GA101467G1, ETFA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101467G2, ETFA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101467G3, ETFA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000126, NM_001127716
• Synonyms: EMA; GA2; MADD
• Summary: 'ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'