Human ETS1 activation kit by CRISPRa

CAT#: GA101470

ETS1 CRISPRa kit - CRISPR gene activation of human ETS proto-oncogene 1, transcription factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ETS1
• Locus ID: 2113
• Kit Components:

  GA101470G1, ETS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101470G2, ETS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101470G3, ETS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001143820, NM_001162422, NM_001330451, NM_005238
• Synonyms: c-ets-1; ETS-1; EWSR2; p54
• Summary: 'This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]'