Human ETV6 activation kit by CRISPRa

CAT#: GA101477

ETV6 CRISPRa kit - CRISPR gene activation of human ETS variant 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ETV6
• Locus ID: 2120
• Kit Components:

  GA101477G1, ETV6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101477G2, ETV6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101477G3, ETV6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001987
• Synonyms: TEL; TEL/ABL; THC5
• Summary: 'This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]'