Human FACL4 (ACSL4) activation kit by CRISPRa

CAT#: GA101523

ACSL4 CRISPRa kit - CRISPR gene activation of human acyl-CoA synthetase long chain family member 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ACSL4
• Locus ID: 2182
• Kit Components:

  GA101523G1, ACSL4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA101523G2, ACSL4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA101523G3, ACSL4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318509, NM_001318510, NM_004458, NM_022977
• Synonyms: ACS4; FACL4; LACS4; MRX63; MRX68
• Summary: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]