Human CD89 (FCAR) activation kit by CRISPRa

CAT#: GA101542

FCAR CRISPRa kit - CRISPR gene activation of human Fc fragment of IgA receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FCAR
• Locus ID: 2204
• Kit Components:

  GA101542G1, CD89 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101542G2, CD89 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101542G3, CD89 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002000, NM_133269, NM_133271, NM_133272, NM_133273, NM_133274, NM_133277, NM_133278, NM_133279, NM_133280
• Synonyms: CD89; CTB-61M7.2; FcalphaRI
• Summary: 'This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]'