Human FGD1 activation kit by CRISPRa

CAT#: GA101568

FGD1 CRISPRa kit - CRISPR gene activation of human FYVE, RhoGEF and PH domain containing 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FGD1
• Locus ID: 2245
• Kit Components:

  GA101568G1, FGD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101568G2, FGD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101568G3, FGD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004463
• Synonyms: AAS; FGDY; MRXS16; ZFYVE3
• Summary: 'This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of the faciogenital dysplasia in Aarskog-Scott syndrome and a syndromatic form of X-linked cognitive disability. [provided by RefSeq, Jul 2017]'