Human FGFR3 activation kit by CRISPRa

CAT#: GA101584

FGFR3 CRISPRa kit - CRISPR gene activation of human fibroblast growth factor receptor 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FGFR3
• Locus ID: 2261
• Kit Components:

  GA101584G1, FGFR3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101584G2, FGFR3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101584G3, FGFR3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000142, NM_001163213, NM_022965, NM_001354809, NM_001354810, NR_148971
• Synonyms: ACH; CD333; CEK2; HSFGFR3EX; JTK4
• Summary: 'This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017]'