Human FGFR4 activation kit by CRISPRa

CAT#: GA101587

FGFR4 CRISPRa kit - CRISPR gene activation of human fibroblast growth factor receptor 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FGFR4
• Locus ID: 2264
• Kit Components:

  GA101587G1, FGFR4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101587G2, FGFR4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101587G3, FGFR4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001291980, NM_002011, NM_022963, NM_213647, NM_001354984
• Synonyms: CD334; JTK2; TKF
• Summary: 'The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]'