Human Fibrinogen gamma chain (FGG) activation kit by CRISPRa

CAT#: GA101588

FGG CRISPRa kit - CRISPR gene activation of human fibrinogen gamma chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FGG
• Locus ID: 2266
• Kit Components:

  GA101588G1, Fibrinogen gamma chain gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101588G2, Fibrinogen gamma chain gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101588G3, Fibrinogen gamma chain gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000509, NM_021870
• Synonyms: fibrinogen, gamma chain; fibrinogen, gamma polypeptide; fibrinogen gamma chain
• Summary: 'The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]'