Human FH activation kit by CRISPRa

CAT#: GA101591

FH CRISPRa kit - CRISPR gene activation of human fumarate hydratase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FH
• Locus ID: 2271
• Kit Components:

  GA101591G1, FH gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101591G2, FH gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101591G3, FH gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000143
• Synonyms: FMRD; HLRCC; LRCC; MCL; MCUL1
• Summary: 'The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008]'