Human FHIT activation kit by CRISPRa

CAT#: GA101592

FHIT CRISPRa kit - CRISPR gene activation of human fragile histidine triad diadenosine triphosphatase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FHIT
• Locus ID: 2272
• Kit Components:

  GA101592G1, FHIT gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101592G2, FHIT gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101592G3, FHIT gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166243, NM_001320899, NM_001320900, NM_001320901, NM_002012, NR_135491, NM_001354589, NM_001354590, NR_148921, NR_148922
• Synonyms: AP3Aase; FRA3B
• Summary: 'The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]'