Human FHL1 activation kit by CRISPRa

CAT#: GA101593

FHL1 CRISPRa kit - CRISPR gene activation of human four and a half LIM domains 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FHL1
• Locus ID: 2273
• Kit Components:

  GA101593G1, FHL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101593G2, FHL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101593G3, FHL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001159699, NM_001159700, NM_001159701, NM_001159702, NM_001159703, NM_001159704, NM_001167819, NM_001449, NR_027621, NM_001330659, NM_001369327, NM_001369329, NM_001369331, NM_001369326, NM_001369328, NM_001369330
• Synonyms: FHL-1; FHL1A; FHL1B; FLH1A; KYOT; SLIM; SLIM-1; SLIM1; SLIMMER; XMPMA
• Summary: 'This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]'