Human FKBP25 (FKBP3) activation kit by CRISPRa

CAT#: GA101600

FKBP3 CRISPRa kit - CRISPR gene activation of human FKBP prolyl isomerase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FKBP3
• Locus ID: 2287
• Kit Components:

  GA101600G1, FKBP25 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101600G2, FKBP25 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101600G3, FKBP25 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002013
• Synonyms: FKBP-3; FKBP-25; FKBP25; PPIase
• Summary: 'The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]'