Human Filamin C (FLNC) activation kit by CRISPRa

CAT#: GA101627

FLNC CRISPRa kit - CRISPR gene activation of human filamin C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FLNC
• Locus ID: 2318
• Kit Components:

  GA101627G1, Filamin C gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101627G2, Filamin C gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101627G3, Filamin C gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001127487, NM_001458
• Synonyms: ABP-280; ABP280A; ABPA; ABPL; CMH26; FLN2; MFM5; MPD4; RCM5
• Summary: 'This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'