Human FMO2 activation kit by CRISPRa

CAT#: GA101634

FMO2 CRISPRa kit - CRISPR gene activation of human flavin containing dimethylaniline monoxygenase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FMO2
• Locus ID: 2327
• Kit Components:

  GA101634G1, FMO2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101634G2, FMO2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101634G3, FMO2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001301347, NM_001460, NM_001365900, NR_160266
• Synonyms: FMO1B1
• Summary: 'This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]'