Human Flavin containing monooxygenase 4 (FMO4) activation kit by CRISPRa

CAT#: GA101636

FMO4 CRISPRa kit - CRISPR gene activation of human flavin containing dimethylaniline monoxygenase 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FMO4
• Locus ID: 2329
• Kit Components:

  GA101636G1, FMO4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA101636G2, FMO4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA101636G3, FMO4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002022
• Synonyms: FMO2
• Summary: Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]