Human FMO5 activation kit by CRISPRa

CAT#: GA101637

FMO5 CRISPRa kit - CRISPR gene activation of human flavin containing dimethylaniline monoxygenase 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FMO5
• Locus ID: 2330
• Kit Components:

  GA101637G1, FMO5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101637G2, FMO5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101637G3, FMO5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001144829, NM_001144830, NM_001461
• Synonyms: flavin containing monooxygenase 5; OTTHUMP00000016306
• Summary: 'Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]'