Human Frataxin (FXN) activation kit by CRISPRa

CAT#: GA101655

FXN CRISPRa kit - CRISPR gene activation of human frataxin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FXN
• Locus ID: 2395
• Kit Components:

  GA101655G1, Frataxin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101655G2, Frataxin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101655G3, Frataxin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000144, NM_001161706, NM_181425
• Synonyms: CyaY; FA; FARR; FRDA; X25
• Summary: 'This nuclear gene encodes a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats results in Friedreich ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]'