Human Ferritin Heavy Chain (FTH1) activation kit by CRISPRa

CAT#: GA101664

FTH1 CRISPRa kit - CRISPR gene activation of human ferritin heavy chain 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FTH1
• Locus ID: 2495
• Kit Components:

  GA101664G1, Ferritin Heavy Chain gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101664G2, Ferritin Heavy Chain gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101664G3, Ferritin Heavy Chain gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002032
• Synonyms: FHC; FTH; FTHL6; HFE5; PIG15; PLIF
• Summary: 'This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]'