Human FUS activation kit by CRISPRa

CAT#: GA101671

FUS CRISPRa kit - CRISPR gene activation of human FUS RNA binding protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FUS
• Locus ID: 2521
• Kit Components:

  GA101671G1, FUS gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101671G2, FUS gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101671G3, FUS gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001010850, NM_001170634, NM_001170937, NM_004960, NR_028388
• Synonyms: FUS-CHOP; FUS1; TLS
• Summary: 'This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]'