Human Glucose 6 Phosphate Dehydrogenase (G6PD) activation kit by CRISPRa

CAT#: GA101687

G6PD CRISPRa kit - CRISPR gene activation of human glucose-6-phosphate dehydrogenase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: G6PD
• Locus ID: 2539
• Kit Components:

  GA101687G1, G6PD gRNA vector 1 in pCas-Guide-CRISPRa

  GA101687G2, G6PD gRNA vector 2 in pCas-Guide-CRISPRa

  GA101687G3, G6PD gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000402, NM_001042351, NM_001360016
• Synonyms: G6PD1
• Summary: This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]