Human GAA activation kit by CRISPRa

CAT#: GA101692

GAA CRISPRa kit - CRISPR gene activation of human glucosidase alpha, acid

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GAA
• Locus ID: 2548
• Kit Components:

  GA101692G1, GAA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101692G2, GAA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101692G3, GAA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000152, NM_001079803, NM_001079804, NR_134848
• Synonyms: LYAG
• Summary: 'This gene encodes lysosomal alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. The encoded preproprotein is proteolytically processed to generate multiple intermediate forms and the mature form of the enzyme. Defects in this gene are the cause of glycogen storage disease II, also known as Pompe's disease, which is an autosomal recessive disorder with a broad clinical spectrum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]'