Human GABA A Receptor alpha 5 (GABRA5) activation kit by CRISPRa

CAT#: GA101701

GABRA5 CRISPRa kit - CRISPR gene activation of human gamma-aminobutyric acid type A receptor alpha5 subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GABRA5
• Locus ID: 2558
• Kit Components:

  GA101701G1, GABA A Receptor alpha 5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101701G2, GABA A Receptor alpha 5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101701G3, GABA A Receptor alpha 5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000810, NM_001165037
• Synonyms: MGC138184
• Summary: 'GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]'