Human GABA A Receptor beta 3 (GABRB3) activation kit by CRISPRa

CAT#: GA101705

GABRB3 CRISPRa kit - CRISPR gene activation of human gamma-aminobutyric acid type A receptor beta3 subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GABRB3
• Locus ID: 2562
• Kit Components:

  GA101705G1, GABA A Receptor beta 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101705G2, GABA A Receptor beta 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101705G3, GABA A Receptor beta 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000814, NM_001191320, NM_001191321, NM_001278631, NM_021912, NR_103801
• Synonyms: ECA5; EIEE43
• Summary: 'This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]'