Human GAMT activation kit by CRISPRa

CAT#: GA101733

GAMT CRISPRa kit - CRISPR gene activation of human guanidinoacetate N-methyltransferase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GAMT
• Locus ID: 2593
• Kit Components:

  GA101733G1, GAMT gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101733G2, GAMT gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101733G3, GAMT gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000156, NM_138924
• Synonyms: CCDS2; HEL-S-20; PIG2; TP53I2
• Summary: 'The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes of this gene are found on chromosomes 2 and 13. [provided by RefSeq, Feb 2012]'