Human GATM activation kit by CRISPRa

CAT#: GA101749

GATM CRISPRa kit - CRISPR gene activation of human glycine amidinotransferase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GATM
• Locus ID: 2628
• Kit Components:

  GA101749G1, GATM gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101749G2, GATM gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101749G3, GATM gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001321015, NM_001482
• Synonyms: AGAT; AT; CCDS3
• Summary: 'This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by cognitive disability, language impairment, and behavioral disorders. [provided by RefSeq, Jul 2008]'