Human GCKR activation kit by CRISPRa

CAT#: GA101765

GCKR CRISPRa kit - CRISPR gene activation of human glucokinase regulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GCKR
• Locus ID: 2646
• Kit Components:

  GA101765G1, GCKR gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101765G2, GCKR gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101765G3, GCKR gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001486
• Synonyms: FGQTL5; GKRP
• Summary: 'This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]'