Human GHRH activation kit by CRISPRa

CAT#: GA101797

GHRH CRISPRa kit - CRISPR gene activation of human growth hormone releasing hormone

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GHRH
• Locus ID: 2691
• Kit Components:

  GA101797G1, GHRH gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101797G2, GHRH gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101797G3, GHRH gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001184731, NM_021081
• Synonyms: GHRF; GRF; INN
• Summary: 'This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]'