Human Ghrelin Receptor (GHSR) activation kit by CRISPRa

CAT#: GA101799

GHSR CRISPRa kit - CRISPR gene activation of human growth hormone secretagogue receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GHSR
• Locus ID: 2693
• Kit Components:

  GA101799G1, Ghrelin Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101799G2, Ghrelin Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101799G3, Ghrelin Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004122, NM_198407
• Synonyms: GHDP
• Summary: 'This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]'