Human GJB1 activation kit by CRISPRa

CAT#: GA101808

GJB1 CRISPRa kit - CRISPR gene activation of human gap junction protein beta 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GJB1
• Locus ID: 2705
• Kit Components:

  GA101808G1, GJB1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101808G2, GJB1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101808G3, GJB1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000166, NM_001097642
• Synonyms: CMTX; CMTX1; CX32
• Summary: 'This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2008]'