Human Galactosidase alpha (GLA) activation kit by CRISPRa

CAT#: GA101814

GLA CRISPRa kit - CRISPR gene activation of human galactosidase alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GLA
• Locus ID: 2717
• Kit Components:

  GA101814G1, Galactosidase alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101814G2, Galactosidase alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101814G3, Galactosidase alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000169
• Synonyms: GALA
• Summary: 'This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008]'