Human GLP1R activation kit by CRISPRa

CAT#: GA101827

GLP1R CRISPRa kit - CRISPR gene activation of human glucagon like peptide 1 receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GLP1R
• Locus ID: 2740
• Kit Components:

  GA101827G1, GLP1R gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101827G2, GLP1R gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101827G3, GLP1R gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002062, NR_136562, NR_136563
• Synonyms: MGC138331
• Summary: 'This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]'